منابع مشابه
Meningitis and meningococcal septicaemia.
Neisseria meningitidis accounted for over half the 2,360 notified cases of meningitis in England and Wales in 19971 and is the leading infectious cause of death in childhood2–4. There were twice as many notifications of meningococcal disease in 1997 as in 1994 and the mortality remained at around 10% (ca 240 deaths)1,2. This article focuses on the presentation and management of meningococcal di...
متن کاملMeningococcal septicaemia and a case of clinically mild illness.
The advent of new investigations for the detection of invasive meningococcal disease may lead to the diagnosis of milder forms of the infection which would previously have remained undiagnosed. In the context of mild disease there may be difficulty interpreting current guidelines and subsequently formulating an appropriate management and public health plan. This case study demonstrates the issu...
متن کاملHeparin therapy in meningococcal septicaemia.
Hunter, J. (1973). Archives of Disease in Childhood, 48, 233. Heparin therapy in meningococcal septicaemia. Two cases of meningococcaemia with bad prognostic signs are presented. In one child a state of disseminated intravascular coagulation and defibrinogenation was established. Heparin therapy was used early and successfully in both cases, supporting the value of early anticoagulation in the ...
متن کاملPathophysiology and management of meningococcal septicaemia.
Whilst an infecting organism may produce toxins which injure tissues directly, this is often inadequate to explain the clinico-pathological sequelae in severe sepsis. Instead, the dominant role in pathogenesis may lie with components of the host immune response to infection. The highly conserved responses of the innate immune system comprise sequential activation and amplification of humoral an...
متن کاملPathophysiology of meningococcal meningitis and septicaemia.
Neisseria meningitidis is remarkable for the diversity of interactions that the bacterium has with the human host, ranging from asymptomatic nasopharyngeal colonisation affecting virtually all members of the population; through focal infections of the meninges, joints, or eye; to the devastating and often fatal syndrome of meningococcal septic shock and purpura fulminans.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1948
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4565.27